
余细勇,男,1962年生,医学博士、研究员、执业医师、教授,1986年获医学学士学位,1989年获医学硕士学位,1998年获医学博士学位。从1997年起先后担任广东省心血管病研究所硕士生导师、博士生导师和博士后合作导师,2004年起担任南方医科大学博士生导师,2006年起汕头大学医学院博士生导师。曾先后留学于香港大学医学院(2000年9月-2001年1月)和美国贝勒医学院(2003年1-8月)从事博士后及国际合作研究工作。现任广东省人民医院、广东省医学科学院院长助理,医学研究中心主任。
主要社会兼职:中国病理生理学会心血管专业委员会副主任委员、国际心脏研究会(ISHR)中国分会执委、美国心脏学会(AHA);中国药理学会理事、中国药理学会心血管专业委员会和临床专业委员会委员、广东省药理学会常务副理事长、美国药理学与实验治疗学会(ASPET)Member;中国中西医结合学会理事、广东省中西医结合学会副会长;国家自然科学基金委员会第十二届专家评审组成员。
学术专长:分子心血管病学和分子临床药理学。
主要研究方向为代谢综合征与慢性心力衰竭的分子机制和潜在的治疗靶点研究,切入点包括3个方面:
①基因治疗与干细胞治疗研究;
②促炎细胞因子的作用机制研究;
③G蛋白偶联受体与慢性炎症的交互作用与网络调控研究。
先后在国内外学术刊物上发表论文300多篇,其中SCI论文40多篇,累计SCI影响因子超过100分。主编或参与编写学术专著7部。主持人体生物等效性试验和药代动力学研究、新药临床前药理与毒理学研究40多项。先后承担国家自然科学基金4项、国家973计划子课题2项、卫生部科研基金3项、省自然科学基金和科技攻关项目10多项、省医学科研基金项目10多项。获广东省医药卫生科技进步奖5项(其中一等奖1项、二等奖1项、三等奖3项),广东省科技技术奖一等奖1项、二等奖3项。申请国家发明专利8项,已获授权发明专利证书6项。到目前为止,共培养硕士、博士研究生及博士后20多人。先后被授予广东省卫生系统“五个一科教兴医工程”学术与技术带头人,“全国中西医结合优秀中青年科技工作者” 称号,葛兰素优秀青年医师奖,广东省十大杰出青年提名奖,国务院政府特殊津贴专家,第八届广东省丁颖科技奖,广东省省直机关岗位排头兵。
近3年发表的主要SCI论文:
1. Kong YZ,Yu XY,Tang JJ, Ouyang XS, Huang XR, Fignerle-Rowson G, Bacher M, Scher LA, Bucala R, Lan HY. Macrophage migration inhibitory factor induces MMP-9 expression:implications for destabilization of human atherosclerotic plaques. Atherosclerosis 2005;178(1): 207-215.
2. Deng CY, Lin SG, Zhang WC, Kuang SJ, Qian WM, Wu SL, Shan ZX, Yang M and Yu XY. Esmolol Inhibits Nat Current in Rat Ventricular Myocytes. Methods Find Exp Clin Pharmacol 2006;28(10): 1-7.
3. Yu XY, Lin SG, Huang XR, Bacher M, Lin L, Bucala R, Lan HY. Macrophage Migration Inhibitory Factor Induces MMP-9 Expression in Macrophages via The MEK-ERK MAP Kinase Pathway. J Interferon Cytokine Res 2007;27(2): 103-109.
4. Li XH, Yu XY*, Lin QX, Deng CY, Shan ZX, Yang M, Lin SG. Bone marrow mesenchymal stem cells differentiate into cardiac phenotype by microenvironment inducement without cell-to-cell physical touch. J Mol Cell Cardiol 2007;42:295-303.
5. Liang YH, Lin SG, Zhou Y, Wang JM, Yu XY. Beta-1 adrenergic receptor antisense-oligodeoxynucleotides ameliorates left ventricular remodeling in 2-Kidney, 1-Clip rats. J Biomed Sci 2007;14:155-164.
6. Deng CY, Yu XY, Kuang SJ, Zhang WC, Zhou ZL, Zhang Kai, Qian WM, Shan ZX, Yang M, Wu SL, Lin SG. Effects of carvedilol on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. Life Sci 2007;80:665-671.
7. Yu XY, Lin SG, Wang XM, Liu Y, Zhang B, Lin QX, Yang M, Zhou SF. Evidence for coexistence of three -adrenoceptor subtypes in human peripheral lymphocytes. Clin Pharmacol Ther 2007;81(5): 645-648.
8. Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Duan W, Chowbay B, Wen JY, and Zhou SF. Role of P-glaycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza bunge. Curr Drug Metab 2007;8(4):325-340.
9. Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, DuanW, Yu XQ, Wen JY, Chowbay B, Li CG, Sheu FS, Chan E, Zhou SF. Tanshinone IIB, a primary active constituent from Salvia Miltiorrhza, exhibits neuro- protective activity in experimentally stroked rats. Neurosci Lett 2007;417(3):261-265.
10. Yu XY, Zhou ZW, Lin SG, Chen X, Yu XQ, Liang J, Duan W, Wen JY, Li XT, Zhou SF. Role of ATP-binding cassette drug transporters in the intestinal absorption of tanshinone IIB, one of the major active diterpenoids from the root of Salvia miltiorrhiza. Xenobiotica 2007;37(4):375-415.
11. Zhong JC, Yu XY*, Huang Y, Yung LM, Lau CW, Lin SG. Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res 2007;74:388-95.
12. Li YX, Yu XY*, Lin SG, Li XH, Zhang SD, Song YH. Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells via CXCR4 chemokine receptor signaling. Biochem Biophys Res Commun 2007; 356: 780-784.
13. Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Yu XQ, Chowbay B, Wen JY, Duan W, Chan E, Li XT, Cao J, Zhou SF. Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of glycyrrhiza glabra. Pharm Res 2007; 24:1668-1690.
14. Zhou ZL, Yang M, Yu XY*, Peng HY, Shan ZX, Chen SZ, Lin QX, Liu XY, Chen TF, Zhou SF, Lin SG. Rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence study. Biomed Chromatogr 2007; 21: 1045-1051.
15. Yu XY, Lin SG, Chen X, Zhou ZW, Liang J, Duan W, Chowbay B, Wen JY, Chan E, Cao J, Li CG and Zhou SF. Transport of cryptotanshinone, a major active triterpenoid in Salvia Miltiorrhiza bunge widely used in the treatment of stroke and alzheimer’s disease, across the blood-brain barrier. Curr Drug Metab 2007; 8(4): 365-377.
16. Zhong JC, Huang Y, Yung LM, Liu CW, Leung FP, Wong WT, Lin SG, Yu XY*. The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regul Pept 2007; 144: 109-114.
17. Li M, Pan XL, Li Y, Wang L, Wu Q, Yu Yu XY, Wang BY and Ning H. Purification of antimicrobial factors from human cervical mucus. Hum Reproduct 2007; 22(7): 1810-1815.
18. Zhou SF, Zhou ZW, Li CG, Chen X, Yu XY, Xue CC, Herington A. Identification of drugs that interact with herbs in drug development. Drug Discov Today 2007;12(15-16): 664-673.
19. Zhong JC, Yu XY*, Lin QX, Li XH, Huang XZ, Xiao DZ and Lin SG. Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. Br J Pharmacol 2008; 153: 66–74.
20. Yu XY, Song YH, Geng YJ, Lin QX, Shan ZX, Lin SG, Li Y. Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1. Biochem Biophys Res Commun 2008;376(3):548-52.
*Correspondence author.
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